Ultra-High Reliability(1)

Robust, User-Friendly Interface

The LCMS-8030 and LCMS-8040 use the same interface. In LCMS analysis, it is necessary to optimize the ionization parameters such as temperatures and gas flow rates to achieve the better sensitivity. ESI needle protrusion and probe position are also factors to be evaluated. In both the LCMS-8030 and LCMS-8040, temperatures and flows are easily controlled through the software. ESI probe position is set by a single easily accessible knob, and ESI needle protrusion is adjusted without the need for any special tools or disassembly of the probe. In addition, this capillary incorporates a tapered design, which reduces sample clogging. Signal-to-noise test results are shown right.In any position, both achieved signal to noise ratios better than sensitivity specifications.

MRM parameters for the LCMS-8030 can be used in LCMS-8040 systems. Optimization of MRM parameters is an early step in LCMS method development. Shimadzu has streamlined the MRM optimization process with a rapid and simplified approach based on automated flow injection analysis. Several method packages, which contain chromatographic and optimized MRM conditions for a variety of analytes, including residual pesticides, veterinary drugs, and forensic drugs of abuse, have also been released. Laboratories employing LCMS-8030 MRM conditions will be able to transfer these MRMs directly to the LCMS-8040. To demonstrate this, a method for the simultaneous analysis of 167 pesticides was transferred without modification from the LCMS-8030 to the LCMS-8040. Increased sensitivity was obtained for all compounds; three example chromatograms are shown below.