Shimadzu 150 Years Anniversary
Shimadzu 150 Years Anniversary

 

 

Clinical History

 

1978

CIM-101A

first clinical ion meter that measures automatically

Shimadzu's first clinical ion meter that automatically measures Na, K, and Cl ions in the blood.

1979

CL-12

clinical chemistry analyzer shimadzu

Shimadzu's first clinical chemistry analyzer.

1989

CL-7200/7300

fully automated clinical chemistry analyzer shimadzu

Shimadzu launched a fully automated clinical chemistry analyzer, the CL-7300, in Japan, utilizing a dual single multi-method with a turntable design. It can perform up to 1200 tests per hour and won the Good Design Award in 1990 (No. 90J0732).

1993

CIM-300

automatically measuring clinical ion meter shimadzu

Shimadzu launched a clinical ion meter in Japan that automatically measures Na, K, and Cl ions in blood, integrating this technology into its clinical chemistry analyzer. It received the Good Design Award in 1993 (No. 93J0585).

1993 - present

Automated blood coagulation analyzer

 

Shimadzu developed its first automated blood coagulation analyzer, the CR-700, in 1993. This line has evolved through the CR-800 (1999), Copapresta 2000 (2007), CP-3000 (2013), and CP-3000α (2025). The CR-700 featured random access and probe pickup methods, while the CR-800 introduced a compact design and innovations.

2017

CLAM-2000 CL

fully automated preparation module for LC-MS shimadzu

Shimadzu has launched the CLAM-2000 CL, a fully automated preparation module for LC-MS. This device automates the entire process from preparing urine, blood, and other biological samples to measurement via liquid chromatography mass spectrometry (LC-MS). As the world's first fully automated LCMS pretreatment device using proven blood coagulation analysis technology, it allows for complete automation of analysis by simply setting the blood collection tube.

2018

DOSIMMUNE™

reagent kit to quantify immunosuppressant drugs shimadzu

Shimadzu Chemistry & Diagnostics, a Shimadzu Grop Company, has released DOSIMMUNE™, a reagent kit to quantify immunosuppressant drugs (Cyclosporin A, Everolimus, Sirolimus, Tacrolimus) in whole blood using LC/MS/MS. This reagent kit, CE marked, is ready-to-use with all the components and accessories required to monitor immunosuppressants in patient whole blood sample.

2020

AutoAmp

genetic analyzer for fully-automatic PCR testing

Shimadzu Corporation has released the AutoAmp Genetic Analyzer (“AutoAmp”) for sale in Japan, enabling clinics to perform fully-automatic PCR testing. With the AutoAmp, classified as a Class I medical device, PCR testing involves simply setting the biological samples, dispensing tips, reagent vials, and reaction vessels in place. This instrument can also be used to detect the novel coronavirus (SARS-CoV-2) using the Ampdirect™ 2019-nCoV Detection Kit of in-vitro diagnostic reagents offered by Shimadzu.

 

CLAM-2030 CL

fully automated sample preparation module for LCMS

 After launching the CLAM-2000 CL in 2017, Shimadzu has released the CLAM-2030 CL, a fully automated sample preparation module for LCMS. The CLAM-2030 improves the stability of internal standards and precipitation reagents, and it features upgraded operational software. These enhancements help stabilize data acquisition, reduce running costs, and improve operational efficiency.

 

Amyloid MS CL AXIMA 

Amyloid MS CL measures amyloid peptides in the blood

Shimadzu Corporation has obtained medical device approval in Japan for the 'Blood Amyloid Peptide Measurement System (Amyloid MS CL),  which measures candidate substances related to the causes of Alzheimer's disease. The 'Amyloid MS CL' measures amyloid peptides in the blood (the main component of amyloid plaques, which are characteristic of Alzheimer's disease) and presents biomarker values related to amyloid β (a protein believed to be a cause of the disease).

 

 

2022

LC-40 CL and LCMS-8045/8050/8060/8060NX CL (IVDR class A)

IVDR Class A device for HPLC

Shimadzu has launched IVDR Class A devices for HPLC (LC-40 CL) and LC-MS/MS (LCMS-8045/8050/8060/8060NX CL). 

2023

CLAM-2040 CL (IVDR class A)

CLAM 2030 paired with IVDR class A

Equipped with a heated ESI probe, the LCMS-8045 has the highest sensitivity in its class. The excellent cost performance of this system is demonstrated in food safety, environmental analysis, and other quantitative analyses. It can be upgraded to the LCMS-8060 and LCMS-8060NX.

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Clinical Stories

Throughout its 150-year history, Shimadzu has gathered numerous stories that exemplify its role in the advancement of analytical technology. Each narrative reflects the contributions of individuals and the evolution of innovations across various fields. Below, we present some of these stories that highlight key milestones in our journey and the impact they have had.

Faster throughput. Together.

Faster throughput. Together.

To face increasing demands on their time and resources, chemical laboratories need easier-to-handle solutions with faster turnaround times, lower costs per sample and full compliance with ever-stricter regulatory standards. Recent work by Alsachim using Shimadzu equipment and software has now led to an optimized high-throughput analytical solution that delivers same-day results for therapeutic drug monitoring of immunosuppressants. The solution combines liquid chromatography and tandem mass spectrometry (LC-MS/MS) with automated sample preparation and a dedicated reagent kit.

Precision beats estimation – GFR measurement by iohexol plasma clearance

GFR measurement by iohexol plasma clearance

The glomerular filtration rate (GFR) plays a vital role in monitoring the kidney function. Even though kidney diseases rank as the 10th leading global cause of death, resulting in 1.3 million deaths annually (2019), the vast majority of GFR determinations are based on estimation (eGFR). These estimations lack clinical accuracy, which can lead to uncertainty in clinical decision-making, especially for critical patient cases. According to the international Kidney Disease: Improving Global Outcomes (KDIGO) organization, reliable and accurate results can only be achieved by direct measurement of the GFR (mGFR) using exogenous markers such as iohexol.

MS detection of Alzheimer’s blood-based biomarkers

Detection of Alzheimers blood-based biomarkers

Amyloid β (Aβ) accumulation in the brain is considered as the earliest sign of Alzheimer’s disease (AD) pathology. Recently developed disease-modifying therapies (DMTs) target patients with early-stage AD, hence blood-based biomarkers are needed for a detection of Aβ accumulation. We combined immunoprecipitation (IP) with mass spectrometry (MS) to develop an IP-MS technique that resulted in the first successful detection of plasma Aβ by MS. This technique revealed a high concordance between a composite biomarker of two plasma Aβ ratios and amyloid PET status. As advances are made in DMTs, blood-based biomarkers will become increasingly valuable due to their key role for screening patients, monitoring drug effects and diagnosis.

 

 

Clinical Events

Are you interested in our Clinical products? You can explore them up close at various upcoming events. Our experts will be available to answer any questions you may have. We look forward to seeing you there!

EACPT 2025

Helsinki, Finland
  • When? 28 June - 1 July 2025 
  • Where? Helsinki, Finland

MSACL 2025

Montreal MSCAL 2025 Shimadzu
  • When? 21 - 25 September 2025 
  • Where? Montreal, Canada

IATDMCT 2025

Singapore IATDMCT 2025 Shimadzu
  • When? 21 - 24 September 2025 
  • Where? Singapore

 

 

Discover our collection of clinical solutions

RECIPE ClinMass® TDM platform with full automation

IVDR Class A devices for HPLC

Shimadzu has been paving the way for automated LC-MS/MS (CLAM series) since 2015 and is nowadays offering a step further to the clinical laboratory's community. Discover the IVD kits from the RECIPE ClinMass® TDM platform now available to be used on Shimadzu automated IVDR class A solutions for LC-MS/MS!

 

 

 

Interested in our clinical solutions?