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Inspired versatility and reliability - The next era of SFC

 

 

"SFC is changing the way we operate by opening the door to new applications."
- Caroline West, Associate Professor, University of Orléans, France, in ‘The Analytical Scientist’ May 2020

 


Shimadzu analytical and semi-preparative SFC instrumentation enables customer- and application-specific solutions supported by a variety of system configurations. Depending on the set-up, our SFC solutions cover highly sensitive SFC-MS applications, a flexible choice between SFC and LC methodology on a single system, offline or online supercritical fluid extraction and analytical or preparative purification using the patented LotusStream GLS technology.

 

 

Supercritical Fluid Chromatography

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Supercritical fluid chromatography (SFC) – chromatography that utilizes pressurized CO2 in the mobile
phase – is seeing a surge in popularity due to its many advantages compared to conventional chromatographic techniques, such as the lower viscosity of the mobile phasethat  allows use of faster flow rates, resulting in higher throughput with reduced solvent consumption. In addition to the SFC’s green credentials, cost per sample can be cut substantially. It also offers complementary chromatographic selectivity to standard reversed phase LC separations, especially beneficial in the separation of chiral compounds. Also, hyphenation of SFC to mass spectrometry (MS) can lead to a significant increase in sensitivity.

 

 

Green technology using CO2

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  • Despite the common misconceptions about "Science Fiction Chromatography", today’s SFC instrumentation is setting new standards with regards to performance and ease of use, making it a reliable, user-friendly addition to the analytical toolbox. Unique hardware innovations make the Nexera UC the state-of-the-art choice for challenging sample separation in a wide range of application areas. This includes chiral screening, pesticide analysis, investigation of biomarkers and determination of polymer additives in the pharmaceutical, chemical and food industries.

 

 

Innovation lead by collaboration

  • The Nextera UC Prep, a next-generation preparative supercritical fluid chromatography system, was developed by Shimadzu in collaboration with the Enabling Technologies Consortium (ETC). ETC, comprised of pharmaceutical and biotechnology companies, provides a forum for companies to share ideas and expertise on the development of novel, useful technologies according to their scientific needs. “The Nexera UC Prep system provides improved hardware and software features that answer the pharmaceutical industry’s demand for an efficient and robust prep SFC system.” 
    (Mirlinda Biba, PhD, Principal Scientist, Merck & Co. Inc.)
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Unparalleled performance, unparalleled flexibility

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New and unique gas-liquid separation (GLS) minimizes sample loss due to eluate scattering during carbon dioxide vaporization, thereby ensuring high recovery rates even for volatile compounds.The patented LotusStream separator decreases the flow rate without increasing the pipe diameter by splitting flow
through multiple channels. The CO2 is discharged externally while the liquid travels along the column and drips directly into the collection vessel without dispersing or scattering the eluate, thereby allowing fractionation of small volumes in collection vessels as small  deep well plates, enabling analytical scale SFC fractionation.
The elegant design of the LotusStream GLS reduces the total size of the recovery system and provides easy cleaning and maintenance.

Explore more solutions for your analysis

Shimadzu offers a broad range of LC and SFC solutions in both analytical and preparative scale, with a variety of optical or MS detectors and suitable software solutions to meet customer requirements.

 

  • Nexera series

    Nexera Series

    Modular HPLC and UHPLC systems with advanced Analytical Intelligence features.

  • LabSolutions MD

    LabSolutions MD

    AI powered HPLC method development software offering DoE and AQbD.

  • Mass Spectrometry

    Mass Spectrometry

    World-class LC/MS instruments with unique automation features and intuitive software.

  • Nexera Prep

    Nexera Prep

    Ease-of-operation in a flexible set-up for preparative LC applications.

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