LCMS-8065XE
Triple Quadrupole LC-MS/MS
To keep pace with evolving laboratory needs, Shimadzu continually enhances its high-performance analytical systems.
The new LCMS-8065XE is a triple-quadrupole mass spectrometer with EVOLVED, EFFICIENT, and EXACT capabilities. These exceptional capabilities ensure high reliability and enhanced productivity, empowering the laboratory for the future.
Reflecting our core philosophy of “Contributing to Society Through Science and Technology”, Shimadzu is committed to addressing current and future challenges by continually advancing the hardware and software of its analytical instruments—delivering meaningful value to society through innovation.
Where limits end, forever begins
Where limits end, forever begins. The Shimadzu LCMS‑8065 XE is a flagship triple‑quadrupole LC‑MS/MS mass spectrometer engineered for laboratories facing evolving analytical demands. By uniting the StreamFocus ion source, IonFocus technology, and the UFSweeper IV collision cell, the system concentrates ions to deliver high sensitivity and trace‑level detection in complex matrices (e.g., PFAS), while enabling ultra‑fast, reliable quantitation. It offers exceptional accuracy, outstanding stability, and reduced gas consumption—supporting more sustainable, high‑throughput workflows and a strong ROI. Guided by Shimadzu’s philosophy of “Contributing to Society Through Science and Technology,” we continually advance our hardware and software to address current and future challenges—empowering your lab to explore what’s beyond.
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Discover the new Shimadzu LCMS-8065XE
- Evolved
Embrace the power of StreamFocus ionization - Efficient
High throughput and best return on investment - Exact
Exceptional accuracy with enhanced sensitivity
- Evolved
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Minimize gas use, achieve greater sensitivity — talk to our team!
Download: Full Product Brochure — New LCMS-8065XE
Explore the LCMS‑8065 XE brochure to discover how Shimadzu’s flagship triple‑quadrupole LC‑MS/MS pushes the limits of sensitivity, speed, and sustainability. Download the brochure for full specifications, compliance/validation options, software integration, and application highlights.
LCMS-8065XE: Explore by Topic
Revolutionary New Technology Achieves Exceptional Performance
Our latest technologies included in the LCMS-8065XE bring sample analysis to a new level. Through evolution of our UF technologies, ESI probe, and collision cell, we are pushing the boundaries to achieve the highest level of performance.
Exploring the Core of High-Sensitivity Analysis
The newly designed StreamFocus ESI probe enhances UFsensitivity analysis by reducing droplet dispersion within the ESI spray. Equipped with a specially engineered low-diffusion nebulizer nozzle, it enables greater ion intake while reducing nebulizer gas consumption—making it particularly, resulting in lower running costs.
The IonFocus unit in the LCMS-8065XE optimizes ion transmission. It solves the common trade-off between contamination reduction and sensitivity loss by using an electrode to focus and direct only target ions into the mass spectrometer, excluding neutral contaminants. This results in high sensitivity, exceptional robustness, and enhanced instrument uptime for reliable, long-term analysis.
New UF Technologies Enable Ultra-Fast Mass Spectrometry Applications
Shimadzu’s triple quadrupole mass spectrometers, powered by a suite of proprietary UF Technologies, have earned widespread acclaim from users across diverse applications. The new LCMS-8065XE incorporates the latest advancements in these technologies, delivering unmatched sensitivity and faster analysis speeds—redefining what’s possible in quantitative mass spectrometry.
UFsweeper™ Ⅳ
Shimadzu's proprietary UFsweeper™ technology—designed to efficiently guide ions through the collision cell without energy loss—has been further refined. The updated collision cell features a larger entrance lens diameter and an increased number of lenses, significantly boosting ion throughput. These improvements result in enhanced ion transmission and greater sensitivity, enabling more precise and reliable quantitative analysis.
Easy Maintenance Shortens Instrument Downtime
Both the desolvation line (DL), which delivers samples to the vacuum section, and the ESI capillary can be replaced quickly and easily. Even the DL can be replaced without breaking vacuum, helping to minimize downtime and maintain laboratory productivity.
Maximizing Overall Workflow Efficiency
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Intelligent tools to help your workflow efficiency generating higher productivity and better data quality.
Preparation
Instrument Check 
PERFORMANCE CONCIERGE makes tuning a mass spectrometer easier than ever before. A tuning standard is automatically introduced into the instrument to verify parameters, including mass accuracy, resolution, and signal strength. Based on these checks, tuning may be automatically initiated to ensure optimal performance. Should the criteria not be met, PERFORMANCE CONCIERGE will diagnose the issue and alert the operator of required maintenance and maximize uptime.
Optimization of Acquisition Conditions
Automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods. LabSolutions Connect MRM not only optimizes target component MRM transitions and collision energies but also maximizes the response for on column analysis. All optimized acquisition parameters are stored in a data base helping to accelerate both method development and routine analysis.
Startup
Integrated intelligence on the Nexera LC series that allows you to increase column life-times and reduce consumables by enabling automated column equilibration for flow rates and temperature.
Reviewing Data and Reporting Results
LabSolutions Insight supports a dynamic quantitative data review landscape with the tools to drive high confidence in result reporting by ‘review by exception’. Insight can be configured to check for any outliers outside the scope of user defined criteria for reporting results.
Data Analysis
Peak Integration
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This example demonstrates the use of Peakintelligence for integration of LCMS peaks of per- and polyfluoroalkyl substances (PFAS). It confirms accurate peak integration even for signals with low signal-to-noise (S/N) ratios. Peak intelligence for LCMS also reduces detection errors caused by baseline noise or undulations to achieve more consistent quantitative analysis results. Revolutionary AI-driven peak detection and integration technology delivers consistent, accurate results even for challenging low signal-to-noise peaks. The intelligent algorithm automatically identifies components and integrates peaks without requiring manual parameter adjustment, while effectively suppressing false positives caused by baseline noise and drift.
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PeakIntelligence dramatically reduces time-consuming manual review processes (up to 67%) and delivers superior reproducibility across complex analyses like PFAS quantification. Experience higher confidence in your results with automated processing that maintains accuracy while accelerating your analytical workflow.
The chromatogram below illustrates the part-per-trillion analysis of a 1 ng/L mixed standard solution of PFAS (Per- and Polyfluoroalkyl Substances). Despite the extremely low concentration of 1 ng/L, the compounds are detected with good peak intensity. The LCMS-8065XE, equipped with the innovative StreamFocus and UFsweeper IV, delivers exceptional sensitivity for the analysis of trace-level components.
The LCMS-8065XE exhibits exceptional robustness during continuous analysis of complex matrices. The data above show both absolute peak areas relative to the initial response and peak area ratios normalized using internal standards, obtained from over 10,000 consecutive injections of treated wastewater samples. To create a more challenging analytical environment, matrix elimination using LC switching valves was deliberately omitted. Even under these challenging conditions, the system retained over 85% of its initial response after 10,000 injections, highlighting its exceptional durability and stability in demanding high-throughput applications.
Championing Sustainability for a Better Tomorrow
High Energy Efficiency
The LCMS-8065XE includes ecology mode functionality that checks the system usage status and automatically shuts down the system if it has not been used for a certain period of time. Using the ecology mode can reduce electricity consumption by about 31%. It also contributes significantly to reducing power consumption by not using LC-MS/MS peripheral equipment except during analysis. Moreover, reducing CO2 emissions contributes to achieving a carbon-neutral society.
Fast-Tracking Sustainability with Nexera UHPLC and LCMS-8065XE
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Combining the LCMS-8065XE with a Nexera series UHPLC system enables ultra-fast analysis and significantly enhances analytical throughput. This increased efficiency also leads to substantial reductions in solvent, gas, and electricity consumption, resulting in lower operational costs.
- NOTE: Power consumption calculations assume 8 hours of analysis on weekdays and no hours on weekends (with ESI interface switched OFF)
Without Ecology Mode
ESI interface remains ON after analysis.
With Ecology Mode
Ecology mode is activated after analysis (with ESI interface switched OFF).
Application Highlights
Explore LCMS‑8065 XE application notes—design, validate, and optimize LC‑MS/MS methods for PFAS, food safety, clinical, and pharma.
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Application Note
An Ultra-high Sensitivity Analysis of 29 PFAS Compounds in Drinking Water by Direct Injection
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Application Note
Breakthrough Sensitivity and Robustness for PFAS Analysis in Chicken Tissue for EPA Method 1633A
Explore more solutions for your analysis
Shimadzu offers a broad range of LC‑MS/MS instruments and complementary UHPLC solutions, combining advanced ionization technologies, intuitive LabSolutions software, and high‑performance capabilities to meet diverse analytical needs.
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The Nexera XS inert system offers the ideal solution for biomolecule separation, combining UHPLC pressure tolerance with a fully inert sample flow path—no wetted metal surfaces—and ultra‑high corrosion resistance.
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The Nexera series is a family of HPLC systems that marries AI and IoT enhancements to set new industry standards.
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Due to increasingly sophisticated automation, large quantities of high-quality mass spectrometer data can be obtained day and night.
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Optional software for the LC/MS/MS Method Packages for Primary Metabolites and Cell Culture Profiling
Features
Videos
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LCMS-8065XE Triple Quadrupole Mass Spectrometer
Where Limits End, Forever Begins; Shimadzu LCMS-8065XE is here. The LCMS-8065XE is the latest triple quadrupole mass spectrometer featuring best-in-class sensitivity synergized with EVOLVED, EFFICIENT, and EXACT capabilities.
EVOLVED: Embrace the power of StreamFocus ionization
EFFICIENT: High throughput and best ROI
EXACT: Exceptional accuracy with enhanced sensitivity